Jane is working as a nurse for Dr. Don Blake on whom she secretly has a crush. Accompanying him on a medical mission to San Diablo, they are attacked by the local dictator called the Executioner. She sees Thor for the first time and is immediately struck by his strength and beauty.
Jane meets Loki for the first time when the God of Mischief comes to Earth to get revenge on Thor.
While having some feelings for her boss Dr. Blake, Jane is becoming more and more fascinated by Thor whom she finds very attractive.
Jane is walking back to the office with Dr. Blake and they meet a carnival mind-reader named Sandu who reveals that the doctor is in love with a woman whose initials are J.F. Jane notes that these are her initials but Donald dismisses it as part of an act.
Jane is appalled when the Radioactive Man threatens to destroy Thor and Dr. Blake walks to his lab as if nothing was happening. Reading the news that the threat is over, she mocks the doctor for doing his routine job while Thor saved the city.
Kidnapped by Professor Zaxton who has apparently gone mad, Jane is rescued once again by Thor.
When Dr. Blake finally comes out of his lab after leaving her with a patient for an hour, Jane Foster blames him for not even showing the courtesy to answer the door that she hammered for half an hour. Tired of making excuses for him, she accuses him of lack of responsibility towards his patients. Later, after an operation, Jane admits that he may lose a few patients in a waiting room, but he has never lost any in the operating room.
Due to Dr. Blake's hesitation to reveal his love for her, Jane decides that she's waited enough. She tells him that she has accepted a job with Dr. Andrews because she feels Blake is too weak to express his feelings and she needs a real man to look after her.
Jane realizes that she cannot stop loving Don Blake, but that despite his apparent mutual feelings for her, a terrible secret seems to keep them apart. After witnessing Mister Hyde's attempt to kill Dr. Blake in his office, she and her beloved boss are abducted by the villain during a dinner date. Hyde takes them to his deserted castle where he ties the doctor next to a time bomb and Jane is forced to follow the villain while he tries to steal the Polaris Submarine. Thor arrives to stop him, but Jane fears that if something happened to Mister Hyde, the bomb would kill Donald so she hides the hero's hammer and the villain is able to escape.
Jane is mortified to find Don Blake in the arms of a gorgeous woman in his office and storms out. While walking the streets, she is abducted by a gigantic man who traps her in the Land of Limbo. She reappears a while later as if nothing occurred, but Thor sends her away while he fights a villain.
Jane is captured by Mister Hyde and the Cobra and heavily injured when an explosion knocks her out. Thor creates a time warp in which he places her until Balder has sent him a cure that saves her.
Lifts the hammer of Thor
Jane is unwittingly subject to Loki's hypnosis.
While Jane is daydreaming about Thor, a group of gangsters burst in to Dr. Blake's office and force him to treat the gun wound of their leader.
Dr. Blake is about to tell something important to Jane but he suddenly tells her he is going to Center Hospital.
Jane is surprised to hear that Thor captured a group of gangsters in Dr. Blake's office.
When they are threatened by the Cobra, Dr. Andrews accepts to collaborate and to provide him with serums from his medical cabinet. Seeing him as a coward, Jane Foster decides to pack her things and go back to work for Dr. Don Blake who would have courageously stood up to the villain.
Seeing that Jane is exhausted following her ordeal with the Executioner, Dr. Blake gives her the rest of the day off.
Jane is disappointed that Dr. Blake does not get jealous when she announces that she has a date with someone else. She understands that he cares for her when he summons Thor to protect her from the Cobra and Mister Hyde but is disgusted at him when she hears on the news that he told the Cobra and Mr. Hyde where to find Thor apparently to save himself.
Thor tells Jane that he is looking for Dr. Blake because he betrayed him to the Cobra and Mister Hyde. Jane Foster pleads in her boss's favor and confesses that she loves Blake. After Dr. Blake has saved New York City from the Grey Gargoyle, Jane proudly shows Thor a news article about it.
Loki enters Dr. Blake's office disguised as an old man and kidnaps Jane. Sent to Limbo, the unconscious girl is rescued by Thor who forces his brother to bring her back.
Jane is disappointed when Dr. Blake cancels their dinner date because a mysterious magnetic disturbance has upset him. Yet she welcomes him later on when he finally shows up at her place.
Jane assists Dr. Blake when he studies Wonder Man's X-Rays.
Dr. Blake finally tells Jane that he is Thor but she does not believe it. As he unsuccessfully attempts to prove it, they are suddenly attacked by the Grey Gargoyle and run away. Shocked unconscious, she awakes in the arms of her boss who has come to his senses and announces that Thor has saved them.
Jane is captured by Loki to lure Thor to Asgard. As the two step-brothers are battling, she wonders why she got involved in their conflict and why Thor would rescue her. The battle is interrupted by Odin who allows Thor to take her back to Earth where he wipes her memory of everything that happened during her abduction.
Jane gets a visit from the Executioner and the Enchantress who try to capture her. Balder, then Thor arrive to protect her. Jane is once more granted the Gift of Forgetfulness and taken home by Balder.
Jane has been missing from Dr. Blake office for a long while. She has been abducted by a mysterious hooded man who claims it is for her own good. As Thor is fighting the Absorbing Man in the streets below, Jane causes a gas explosion in the apartment to attract the hero's attention. But the gas makes her unconscious and she wakes up in a hospital under Dr. Blake's care, still ignorant of who her captor was.
